( Borrelia miyamotoi )
18 - 24
18 - 24
- A cycle of symptoms appearing and disappearing begins within 2 weeks of exposure.
- Symptoms last 3-5 days of symptoms before they disappear for 1-2 weeks. They then reappear for another 3-5 days.
- The cycle continues until treatment and could occur up to 10 ten times over several weeks or months.
- Symptoms include:
- Chills, sweats, headache, dizziness, fatigue, nausea, vomiting, fever
- Joint and muscle pain
- Disorientation, loss of memory and lack of coordination
- Low platelet count and kidney dysfunction are possible symptoms.
- Meningoencephalitis and other central nervous system symptoms may occur if left untreated.
Diagnosis and Treatment
- A nonspecific ELISA test can detect antibodies specific for Borrelia miyamotoi as early as 1 week after infection.
- Western blot assay is used to confirm ELISA results.
- When symptoms are present, a thin or thick blood smear may show infection.
- Borrelia miyamotoi DNA in serum can be confirmed via Polymerase Chain Reaction.
CDC Treatment Recommendation
- Adults: Doxycycline 100mg- 2x daily, Cefuroxime axetil 500mg- 2x daily, or Amoxicillin 500mg- 3x daily for 10-21 days
- Children: Doxycycline 4mg/kg divided into 2 doses daily, Cefuroxime axetil 30mg/kg divided into 2 doses daily, or Amoxicillin 50mg/kg divided into 2 doses daily for 10-21 days
- Borrelia miyamotoi enters the hosts blood stream, affecting multiple organs.
- Symptoms are reduced temporarily when the immune system creates antibodies against the surface of the pathogen.
- Surviving Borrelia miyamotoi cells will change their surface so the immune system can’t recognize them.
- Symptoms will appear again after Borrelia miyamotoi replicates and spreads.
- New antibodies are created and symptoms are reduced.
- Remaining bacterial cells will change their surface again and the cycle continues until the patient is treated with antibiotics.