Rocky Mountain Spotted Fever
(Rickettsia amblyommii, Rickettsia rickettsia & Rickettsia parkeri)
18 - 24
18 - 24
- Symptoms typically occur 2-12 days after a tick bite
- Headache, fever, nausea, and vomiting may be occur first followed by a quick progression into more severe and life threatening symptoms
- A spotted rash varying in presentation will occur in most patients.
- Blood vessel damage may lead to amputation if left untreated.
- Mental and physical disability occur in severe cases.
Diagnosis and Treatment
- Immunostaining of skin biopsies can confirm the presence of Rickettsia amblyommii & Rickettsia spp.
- Indirect Immunofluorescence Assays (IFA) is a two-part test used to detect antibodies.
- The first sample is collected within 7 days of infection and will be compared to the second sample collected 2-4 weeks after infection.
- If the second sample shows the number of antibodies present has increased since the first sample was tested, the results are positive for Rickettsia.
- False positives are common for the first part of the test.
- Blood test results of low platelet count, low sodium levels, or elevated liver enzyme levels can assist with diagnosis.
CDC Treatment Recommendation
- Adult: Doxycycline 100mg-2x daily for 5-7 days
- Children: 2.2mg/kg-2x daily for 5-7 days
- Rickettsia species will infect cells that line blood vessels causing vascular inflammation known as Rickettsial vasculitis.